Solutions

In-Situ CIP-SIP System

Automated Cleaning-In-Place and Sterilization-In-Place systems for repeatable cleaning and sterilisation of pharmaceutical equipment and piping.

Overview

Repeatable Cleaning and Sterilisation in Place

Esteril designs and manufactures Cleaning-In-Place and Sterilization-In-Place systems for automated cleaning, sanitisation and sterilisation of pharmaceutical process equipment and piping.

 

The modular, skid-mounted systems deliver efficient, repeatable cleaning cycles for fixed equipment, multi-tank systems and aseptic setups. Available in fully automated and semi-automated configurations, each is customised to the process and production capacity, giving multiproduct facilities effective contamination control, process consistency and regulatory compliance.

In-situ CIP SIP system automated pharmaceutical manufacturing

Configuration

Automated / semi-automated

Compliance

cGMP · ASME BPE · 21 CFR Part 11

Contact parts

SS 316L, electropolished

Automation

PLC / SCADA with HMI

Where it fits

Applications

Cleans and sterilises fixed equipment and piping across the facility.

Applications

Manufacturing vessels and holding tanks
Process piping systems
Bioreactors and fermenters
Filtration and transfer systems
Aseptic pharmaceutical processing equipment

Built for

Fully automated or semi-automated cycles
Online acid and alkaline dosing
Single-tank to large multi-tank systems
Cleaning validation with riboflavin test
Integration with existing equipment

Skid-mounted with no separate installation required.

How it’s engineered

Advantages and Key Features

Why it's specified

Compact skid-mounted design with no separate installation
Custom-designed to product flow requirements
Heating and cooling integration options
Reliable full or semi-automated operation
Tailor-made solutions for custom applications
Reduced manual intervention and improved efficiency

What's built in

Sanitary design as per US FDA, cGMP and ASME BPE standards
SS 316L contact parts, mirror and electropolished
SS 304 non-contact parts with matt finish
Hygienic orbital tube welding
Online acid and alkaline dosing provision
Sanitary moisture separator and pressure regulating valve
Automation compliant to USFDA 21 CFR Part 11
Cleaning validation with riboflavin test
Recipe-based process parameter settings
Load cells and level sensors for accurate monitoring

Specifying questions

Frequently Asked Questions

CIP, Cleaning-In-Place, cleans equipment and piping without dismantling them. SIP, Sterilization-In-Place, sterilises the same equipment in position, usually with clean steam. Esteril builds both into a single automated system.

Yes. Configurations run from single-tank setups to large fixed multi-tank systems, sized to the facility and cleaning cycle required.

Through cleaning validation including the riboflavin coverage test, with cycle data logged by the automation system for documentation.

It is available in fully automated and semi-automated configurations, with PLC control, recipe-based parameters and time and temperature control, compliant to 21 CFR Part 11.

No. The system is compact and skid-mounted, so no separate installation footprint is required.

Let's build it together

Standardising your cleaning cycles?

Tell us the equipment and tanks you need to clean, and our engineers will scope a CIP-SIP system to match your process.